Monocyte distribution width (MDW) and DECAF: two simple tools to determine the prognosis of severe COPD exacerbation.

Monocyte distribution width (MDW) has been associated with inflammation and poor prognosis in various acute diseases. Chronic obstructive pulmonary disease (COPD) exacerbations (ECOPD) are associated with mortality. The objective of this study was to evaluate the utility of the MDW as a predictor of ECOPD prognosis. This retrospective study included patient admissions for ECOPD. Demographic, clinical and biochemical information; intensive care unit (ICU) admissions; and mortality during admission were recorded. A total of 474 admissions were included. MDW was positively correlated with the DECAF score (r = 0.184, p < 0.001) and C-reactive protein (mg/dL) (r = 0.571, p < 0.001), and positively associated with C-RP (OR 1.115 95% CI 1.076-1.155, p < 0.001), death (OR 9.831 95% CI 2.981- 32.417, p < 0.001) and ICU admission (OR 11.204 95% CI 3.173-39.562, p < 0.001). High MDW values were independent risk factors for mortality (HR 3.647, CI 95% 1.313-10.136, p = 0.013), ICU admission (HR 2.550, CI 95% 1.131-5.753, p = 0.024), or either mortality or ICU admission (HR 3.084, CI 95% 1.624-5.858, p = 0.001). In ROC analysis, a combined MDW-DECAF score had better diagnostic power (AUC 0.777 95% IC 0.708-0.845, p < 0.001) than DECAF (p = 0.023), MDW (p = 0.026) or C-RP (p = 0.002) alone. MDW is associated with ECOPD severity and predicts mortality and ICU admission with a diagnostic accuracy similar to that of DECAF and C-RP. The MDW- DECAF score has better diagnostic accuracy than MDW or DECAF alone in identifying mortality or ICU admission.

Integrated Management of Pig Residues and Copper Mine Tailings for Aided Phytostabilization.

There is high demand for identifying socio-environmentally sound ways to dispose of large quantities of offensive odor-generating organic residues produced by intensive livestock farming. The use of these residues as amendments at large-scale mine tailings storage facilities for in situ plant-based reclamation may be a useful alternative. We performed a greenhouse assay to evaluate effectiveness of pig slurries and the solid organic fraction of aerobic-aerated pig slurries, both treated and not treated for odor emission, as amendments for copper tailings. Different doses of slurries or the solid organic fraction of the slurries, untreated and treated with either ozone or a commercial product used to manage strong odors (Just a Drop), were incorporated into tailings and stabilized (15 d) under greenhouse conditions. L. (ryegrass) was used as bioindicator for Cu and Zn toxicity. Plant performance (shoot and root dry biomass, Cu and Zn content in leaves) and general physicochemical characteristics of substrates were evaluated. Our results showed that odor management of pig residues was possible with commercial products, and their incorporation into tailings rapidly and effectively reduced odor emission. The solid organic fraction of the slurries neutralized acidic tailings, and both pig residues increased organic matter and nutrient content in tailings while reducing extractable Cu. As a result, ryegrass productivity was significantly improved by incorporation of either slurries or their solid organic fraction into tailings in a dose-dependent form. Foliar Cu content in ryegrass was not affected but foliar Zn content increased; however, Zn remained within acceptable ranges. Both the pig slurries and their soil organic fractions proved to be valuable residues for tailings reclamation.

Effectiveness of pig sludge as organic amendment of different textural class mine tailings with different periods of amendment-contact time.

The present study assesses the effect of tailing texture (loamy sand (LT) and sandy loam (ST)), dose of pig sludge (0, 50, 100 and 200 t ha-1) and amendment-contact time (14, 28 and 42 days) on physicochemical quality of amended substrate using Lolium perenne var Nui as a bioindicator. The main properties of LT differed of ST in levels of total organic carbon (0.19 and 0.58%), in pH (4.6 and 8.5), total Cu (202 and 1647 mg kg-1) and Zn content (31 and 137 mg kg-1). Soil pore water of experimental substrates was characterized for pH, electrical conductivity (EC) and Cu2+ ion activity (pCu2+) while ammonium nitrogen (NH4+-N), infiltration rate and general physicochemical characteristics were measured in substrates. Shoot biomass (SB), root biomass (RB) and the RB:SB ratio was calculated for L. perenne. The results showed there to be a significant interaction (p < 0.05) between tailing texture, sludge dose and amendment-contact time for pCu2+, infiltration rate, SB, RB, and RB: SB ratio, but not for pH, EC, or NH4+-N. However, sludge dose and amendment-contact time significantly affected all variables. By increasing dosages of pig sludge, pore water pH increased, and this was associated with decreases in pCu2+ and the infiltration rate. High doses of pig sludge (100 and 200 t ha-1) impaired growth of L. perenne irrespective of tailing texture and amendment-contact time, likely because of the rise of EC (up to 14 mS cm-1). For both tailing textures, the highest biomass was obtained after incorporation of 50 t ha-1 of pig sludge, with increasing values as amendment-contact time rose. In conclusion, effective management of pig sludge for tailing reclamation should guarantee doses <50 t ha-1 and amendment-contact time >28 days, irrespective of tailing texture.